Findings: RCTSemaglutide vs Placebo for Alcohol Use Disorder in Adults, JAMA Psychiatry (2025) [PubMed abstract] Design: Randomized, placebo-controlled trial (N=48 | length = 9 weeks) in non-treatment-seeking adults with alcohol use disorder Treatment: Semaglutide (0.25 mg/week for 4 weeks, 0.5 mg/week for 4 weeks, and 1.0 mg for 1 week) vs Placebo Primary outcome: Objective alcohol self-administration (at baseline and between Weeks 8 and 9) measured as follows: a standardized procedure was used to estimate voluntary alcohol consumption and ability to delay drinking
Notably, three weeks prior to the onset of illness, the patient had completed his fourth injection of a weight-loss medication (BGM0504), administered biweekly at doses of 2.5 mg, 2.5 mg, 5 mg, and 5 mg, respectively (Table 1)
53(3): 338-344 Health Canada
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Mechanism of Action Comparison# Ribupatide# Ribupatide is a dual GLP-1/GIP receptor agonist peptide that simultaneously activates both incretin receptors
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