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Several studies have pointed to PI3K activation as a pivotal event for estradiol effects, a common pathway for IGF-I and insulin[344]
Huenchuguala, S
UK Biobank The UKBB is a large-scale biomedical database and research resource containing in-depth genetic and health information from half a million UK participants
& Gilbert, I
However, these results should be interpreted with caution due to high heterogeneity that was observed among the studies included in this meta-analysis
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