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Um, but its not the peptides fault that the management of the patient, the dosing, and then the compliance issue of the patient

However, oral administration is gaining traction, led by Rybelsus, the first oral GLP-1 approved by the FDA

10.1111/bph.13616 31 CortiA.DominiciS.PiaggiS.BelcastroE.ChiuM.TaurinoG.et al (2019)

In S2, we did not observe a strong, meal schedule independent reduction in feeding that would have been expected given a sustained pharmacological effect, but neither did we find compensatory consumption after the reduced S1 feeding rates that would have been expected due to declining drug effects