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3.3 mPTP identification and sensitivity of mPTP to calcium in the heart of glutathione-treated old rats Figure 2 shows typical kinetic curves of spontaneous mitochondrial swelling in Ca 2+ free medium and under conditions of calcium loading as well as changes in sensitivity of mitochondria to a wide range of Ca 2+ concentration under our study conditions

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All analyses were conducted using the SPSS Statistics 19.0 software (IBM, USA)

Plasma glutathione is typically lower (15 mol/L) and reflects acute oxidative demand