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This study further developed a cell death-related signature (CDS) based on CASP1, CYBB, PLA2G4A, and CTSS, providing an effective diagnostic tool that tightly correlates with progressive renal function decline and local immune microenvironment remodeling (135)

Summary: Current clinical evidence does not show that GLP-1 medications cause thyroid cancer in humans, despite thyroid tumours observed in animal studies

The landmark FLOW trial , published in the New England Journal of Medicine in 2024, demonstrated that semaglutide reduced the risk of major kidney disease events by 24% in patients with type 2 diabetes and chronic kidney disease (hazard ratio 0.76

further demonstrates that histone lactylation is a novel epigenetic mark that stimulates gene transcriptional activity on chromatin in response to elevated intracellular lactate levels, and is particularly prominent during M1-type macrophage polarization

Most investors are of the view the stock is overpriced and are interested only at a discount to the current level

July 6, 2022