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NICE technology appraisal TA875 (2023) recommends semaglutide 2.4 mg (Wegovy) as an adjunct to a reduced-calorie diet and increased physical activity for adults with a BMI of 35 kg/m or above (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, when initiated within specialist weight management services

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As with vegetarians, vegans can avoid this by consuming a dietary supplement or eating B 12 fortified food such as cereal, plant-based milks, and nutritional yeast as a regular part of their diet

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Restores NAD+ pools while activating AMPK