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Tirzepatide slows stomach emptying as part of its weight loss mechanism, which can increase the risk of gastrointestinal irritation when combined with nonsteroidal anti-inflammatory drugs like ibuprofen

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Therefore, patients are likely informed when they make purchasing decisions and Novo Nordisk may not be able to present evidence of confusion through survey or other means

doi: 10.1590/S0100-204X2006000100001 14