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~50%), but with higher discontinuation rates and a novel side effect (dysesthesia)

Significant main effects of treatment group (prior to BenjaminiHochberg correction since none were significant after correction, although the necessity of correction for multiple comparisons in exploratory analyses remains unresolved 49 ) were observed for the unclassified group and ten classified genera, namely, Acetatifactor , Akkermansia , Erysipelatoclostridium , [ Eubacterium ] coprostanoligenes group , Family XIII UCG-001 , Lactobacillus , Parasutterella , Ruminiclostridium 6 , Ruminococcaceae UCG-004 , and Ruminococcaceae UCG-009

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But if glycaemic benefit really does plateau around 9 mg while weight loss and adverse events keep climbing, then dose selection in the patient whose primary problem is glycaemic becomes a real clinical decision rather than a titrate-to-max reflex

1 2 3 4 "Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology"