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As in Phase-I HSB, phosphocreatine was not detected in the plasma of Phase-II HSB

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GSH synthesis and consumption The synthesis of GSH relies on cysteine as the starting material, and cellular resistance to lipid oxidation depends on intracellular cysteine levels, primarily produced by the system Xc and transsulfuration pathways

GSH is found in all mammalian tissues as the most abundant non-protein thiol that defends against oxidative stress and possess a distinctive stability provided by a -carboxyl bond within the molecule (Figure 1A)