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The brain is particularly vulnerable to oxidative stress due to its high oxygen consumption, abundant polyunsaturated fatty acids, and relatively modest antioxidant defenses compared to other organs [1][2][48]

Specifically, oxidative stress, mitochondrial dysfunction and neuroinflammation are the primary focus of this chapter as they are all closely related to NADPH oxidase function

Additionally, pine bark extract functions as a potent agent in counteracting skin aging caused by sun exposure, while alpha lipoic acid and grape seed extract contribute with their antioxidant properties to protect skin cells from damage

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Proteasome inhibitor-induced apoptosis in CLL is associated with immediate disruption of mitochondrial function