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Possible Side Effects and Safety Considerations The most common side effects are gastrointestinal including nausea, vomiting, and diarrhoea typically peaking during dose escalation

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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, thereby being roughly four times higher than those in normal rats

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