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Published Phase 2 and Phase 3 trials for both molecules enrol as monotherapy (with or without background T2D therapy such as metformin or insulin)
Clinical studies demonstrate average weight loss of 14.9-17.4% of body weight over 68 weeks
Preexisting conditions included (1) annual claims exceeding $500,000 in any year 20222024 and (2) blood disorders, end stage renal disease, cancer, or prior bariatric surgery during the 6month preperiod before GLP1 initiation
This helps the product absorb completely and allows for better penetration of the active ingredients
2004[Cited 2019 Nov 17]
doi:10.1152/ajpendo.00201.2006 (source) Ionescu M, Frohman LA
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