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Metabolic flexibility is the ability of a cell to efficiently switch between burning carbohydrates and fats depending on nutrient availability and immediate energy demands without suffering oxidative damage

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Fatigue is listed as a common adverse reaction in the Summary of Product Characteristics for several GLP-1 medications, particularly at higher doses used for weight management

Information on medications that are more likely to cause hypoglycemia should be provided, and patients taking acarbose or miglitol should be cautioned that only dextrose will raise blood glucose during a hypoglycemic episode

The guidelines are for people at high risk to be screened with a routine blood test at least once a year

doi:10.1001/jamaophthalmol.2024.2296 Lisco G, De Tullio A, Disoteo O, et al