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The peptide also demonstrates remarkable safety in animal models
In cardiac cells, the physical proximity between mitochondria and the sarcoplasmic reticulum (SR, a specific type of ER in heart and skeletal muscle cells) allows the exchange of Ca 2+ in local microdomains, providing rapid Ca 2+ buffering
Overall, GLP-1RAs represent a promising avenue for treating autoimmune and autoinflammatory diseases, though significant research gaps remain
American Journal of Geriatric Psychiatry, 10(5), 503-505
This concept of "biased agonism" is central to understanding why structurally similar compounds acting on the same receptor can produce different downstream effects
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