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That distinction matters clinically because it preserves the feedback loop that governs GH secretion, reducing the risk of the side effects associated with exogenous HGH administration at therapeutic doses

2004;97(2):c41-c48

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Because dietary vitamin E is essential to prevent vitamin E deficiency in newborns, vitamin E must be supplied in parenteral nutrition solutions in infants who cannot be given enteral feeding, such as prematurely born infants