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Early clinical trials have shown large, dose-related weight loss in people with obesity

The discrepancy between this study and the data herein may reflect the heterogeneous nature of CD and disease severity between the patient donors (the current study used monocytes from individuals with mild-to-moderate CD), the mechanisms of action of the various pro-death stimuli, or differences in apoptotic versus non-apoptotic death in macrophages

Front Pharmacol 15:1405423

Called Byetta, it had been approved by the FDA the previous year

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Numerous clinical studies have demonstrated meaningful weight loss and improvements in overall metabolic health for many patients