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Long-term and short-term animal studies have reported no consistent evidence of organ toxicity or reproductive disruption under controlled laboratory conditions

However, a chasm is present for large scale studies to see the role GLP-1RA in neurological diseases including ocular pathologies, present studies are inconclusive about the implications in long term preventions in different populations

20 Monitor patients at least once a year if they do have additional risk factors besides taking GLP-1 drugs