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279,280 Both antiplatelet and anticoagulant actions have been reported
Understanding these differences is essential for designing precise and reproducible experiments
A potential concern with dietary supplements is the lack of regulatory oversight
Systemic administration typically suits joint applications given the difficulty of accessing intra-articular spaces without specialized medical procedures
233-235 In a randomized controlled trial in 84 subjects with coronary artery disease, 30 mg per day of crocin for eight weeks lowered levels of oxidized LDL and an inflammatory marker (monocyte chemoattractant protein-1, or MCP-1), and inhibited expression of genes related to atherosclerosis compared with placebo
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