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although several candidate genes such as MAP4K4, E2F6 , and UBE2N have demonstrated preclinical promise, their translation into clinical settings remains at an early stage, highlighting the need for further in vivo validation and tumor-specific delivery strategies

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Spray administration: Administer a measured amount of the TB-500 nasal spray by gently pressing the applicator, releasing the spray into the subject's nostril

PMC 5282855