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However, mechanistic data are very limited, and definitive conclusions regarding their contribution to MASH cannot yet be established

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The Lau monotherapy data cuts through that by showing the amylin analog producing double-digit weight loss entirely on its own, which is the cleanest argument that adding it to a triple agonist brings genuinely additive firepower rather than redundant signalling

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doi: 10.1016/j.anireprosci.2023.107249 26 MontjeanDEntezamiFLichtblauIBellocSGurganTMenezoYet al