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Thiazide & Thiazide-like Diuretics Site: Distal Convoluted Tubule (DCT) Thiazides: Hydrochlorothiazide Chlorothiazide Thiazide-like: Chlorthalidone Indapamide Metolazone Uses: Hypertension, mild edema, nephrogenic diabetes insipidus 5

The medication may also affect other conditions such as pancreatic or kidney disease, and it can influence how other medications are absorbed

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For instance, the Michael acceptor methylene quinuclidinone, the active form of APR-246, was shown to be a potent and direct inhibitor of both TXNRD1 and Glutaredoxin-1 (GRX1) by reacting with the selenocysteine group in both enzymes

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