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Although liraglutide is the most studied GLP-1 agonist in psychiatric patients and is available in a generic form, it requires daily dosing and is less effective than the branded, once-weekly GLP-1 agonists semaglutide and tirzepatide.

While direct trials pairing Lipo C with semaglutide or tirzepatide remain limited, metabolic studies confirm that adequate B vitamin status supports cellular energy efficiencya logical complement to appetite-suppressing GLP-1 therapy

The study also shows that markers of neuronal cell stress and apoptosis, namely metalloproteinase-3, were significantly reduced upon the administration of GLP-1 [70]