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(1987) Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy
This upregulates genes involved in fatty-acid uptake/oxidation, OXPHOS, the TCA cycle, and mitochondrial biogenesis, shifting substrate use toward lipids and increasing energy expenditure
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41 Hvas, A.-M., Juul, S., Lauritzen, L., Nex, E
Nat Rev Rheumatol 19 , 403416 (2023)
Best for very small doses and low concentrations
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