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184,185,199 Rational combinations, such as PARPis plus ATR or WEE1 inhibitors, aim to exacerbate replication stress and collapse replication fork stability, particularly in tumors with partial or context-specific DDR competence

The MD criteria score rates MD as not likely (1), possible (24 points), probable (57 points) or definite (8 points)

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HIV-1 Tat promotes lysosomal exocytosis in astrocytes and contributes to astrocyte-mediated tat neurotoxicity

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MDR-001s superior preclinical efficacy and safety profiles indicate its best-in-class potential for obesity and type 2 diabetes mellitus indications with large unmet medical needs