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Post hoc comparisons revealed a significant increase in appetite scores in the control group from pre- to post-alcohol administration (B = 23.27, t(18) = 5.0, p = 0.0005), while the GLP-1RA group showed no statistically significant change (B = 7.30, t(18) = 1.57, p = 0.41), however the GLP-1 group started with a slightly, but not significantly, higher baseline
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Aside from a 27% reduction in the co-primary endpoint of CV death or HHF (largely driven by HHF reduction), dapagliflozin reduced the risk of 40% decline in eGFR to 33.9 mg/mmol), a sustained decline in eGFR of 30% or more from baseline, or chronic RRT (HR 0.85, 95% CI 0.77-0.93
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Single supplier batch matching across the three compounds (where all compounds in the research design come from the same verified supplier and are tested against the same documentation standard) is the preferred sourcing model for combined research protocols
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