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The mechanism of action, particularly BDNF upregulation, neuroplasticity enhancement, and microglial optimization, is theoretically supportive of cognitive enhancement in healthy brains

In line with BSSM guidance and testosterone SmPCs (e.g., Nebido), TRT should be paused or the dose reviewed if haematocrit exceeds 0.54

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surrogate endpoints (weight, HbA1c) are not hard outcomes

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It helps maintain mitochondrial membrane potential and prevent the release of pro-apoptotic factors from mitochondria, thereby preserving cell viability (Pang, 2015)