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This work was also supported by Key R&D Program of Anhui Province (to SX), Program for Innovative Research Team of The First Affiliated Hospital of USTC (to JW), Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01S131], China International Medical Foundation (to XZ), Natural Science Foundation of Anhui Province [Grant No

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a risk factor for neurodegeneration