If side effects are bothersome, staying at the current dose for an extra 2-4 weeks before escalating is common in trial protocols and doesnt blunt long-term results
This muscle deterioration can lead to increased thoracic kyphosis (rounded upper back), forward head posture, and tension headaches
A post-hoc analysis reported alongside the publication demonstrated efficacy independent of the number of prior antidepressant treatment failures, with Day 8 remission rates of 53.9%-63.6% across subgroups
These correlations would provide better risk estimates for patients with multiple risk factors such as diabetics taking GLP-1 RA for glucose management in determining possible outcomes for either continuation or temporary discontinuation of the medications to best prevent pulmonary aspiration while optimizing outcome (Ushakumari and Sladen 2024)
Sandberg O, Franklin KA, Bucht G, Gustafson Y
Just a flat, stable background insulin level that mimics what a healthy pancreas provides between meals and overnight