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Sitagliptin, a dipeptidyl peptidase-4 inhibitor, was selected as an active-comparator placebo proxy because it was recommended in clinical guidelines as a second-line glucose-lowering therapy, had a similar high cost to the study drugs, showed no effect on cardiovascular outcomes in a large randomized controlled trial and has been validated as a placebo proxy in prior claims-based research 20,41
When total caloric intake drops dramatically and protein is not prioritized, the body may utilize muscle tissue to meet metabolic demands
Preprint at SSRN (2025)
PDE2A shows regionally divergent alterations in schizophrenia, with reductions in the amygdala, cingulate cortex, and orbitofrontal cortex but elevated expression in the hippocampus, suggesting compensatory rather than pathogenic involvement
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