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Document what changed and by how much
A recent 2025 study showed that participants who consumed 1 gram of berberine daily for 6 months had no meaningful change in adiposity (AKA the accumulation of body fat) 19
Front Endocrinol (Lausanne) (2013) 4:166
Melanin is synthesized through oxidation of tyrosine to dopamine and eventually melanin in the melanosome (12)
Bottom line Zepbound does not directly cause body aches but reports of muscle pain and body aches while taking Zepbound are not uncommon
My work was preclinical, though, so I didnt get to hear about the translational benefits for patients
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