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This can occur when people lose weight quickly

You work hard, cut calories, and push yourself, only to see the weight come back or the results stall

Work with a specialist to develop a plan for weight maintenance after stopping Wegovy, as most patients regain some of the lost weight after stopping new drugs such as Wegovy that reduce hunger levels

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Sources: Ionescu M, et al

We next identify and map sites of cholesterol high occupancy and residence time on active versus inactive GLP-1Rs using coarse-grained molecular dynamics (cgMD) simulations, followed by a screen of key residues selected from these sites and detailed analyses of the effects of mutating one of these residues, Val229, to alanine on GLP-1R interactions with cholesterol, plasma membrane behaviours, clustering, trafficking and signalling in pancreatic beta cells and primary islets, unveiling an improved insulin secretion profile for the V229A mutant receptor