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Fatty acids are utilized as an energy substrate in all tissues, and although glucose is the main energetic substrate in adult brain, fatty acids have also been shown to be utilized by brain as an energy substrate

Duffy JF, Wang W, Ronda JM, Czeisler CA

Patients with metabolic comorbidities: Autoimmune patients with concurrent insulin resistance, metabolic syndrome, or cardiovascular risk factors benefit doubly, since the GLP-1 addresses both the autoimmune inflammation and the metabolic burden