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This is why research suggests that an optimal combination of the three vitamins, B1, B6 and B12, is more effective at relieving nerve damage symptoms and restoring nerve function than taking a single vitamin supplement
Repeated freeze-thaw cycling of prepared solutions should be avoided
NNMT transfers a methyl group from SAM onto nicotinamide, producing 1-methylnicotinamide while consuming methyl donors and contributing to NAD depletion
However, this does not mean everyone will feel more energetic after a B12 injection
Accessed Janaury 14, 2025
Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist
