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Animal research has demonstrated efficacy via oral administration, particularly for GI-related applications
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doi:10.1186/s12933-014-0129-4
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This is why purchasing from vendors with recent lot-specific COAs and using solutions promptly matters more than visual inspection
However, the generic formulation of cyanocobalamin has a strict warning against use in patients with Lebers disease (a rare genetic eye disease), as it can cause rapid and severe optic nerve atrophy leading to blindness
