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In vitro and in vivo studies demonstrated that TPZ-loaded nanoparticles generated higher levels of reactive oxygen species, induced greater DNA damage, and achieved stronger tumor growth inhibition compared to free TPZ, while reducing systemic toxicity (303)
20 Scarring and adhesions affecting one or both fallopian tubes can block movement of oocytes and sperm, preventing fertilization
Maiti A, DiNardo CD, Cortes JE, Borthakur G, Pemmaraju N, Benton CB, Kadia TM, Takahashi K, Naqvi K, Ravandi F, Alvarado Y, Short NJ, Daver NG, Sasaki K, Ohanian MN, Garcia-Manero G, Thompson PA, Kornblau SM, Masarova L, Jain N, Jabbour EJ, Andreeff M , Maduike R, Guerrero JA, Zhang Q, Cavazos A, Ma H, Rausch CR, Bivins CA, Vaughan K, Pierce SA, Ning J, Qiao W, Welch JS, Kantarjian HM, Konopleva MY
These findings confirmed that the SunPDT microneedle patch possessed robust mechanical strength, which is highly advantageous for portability and wearability in the later stages of the treatment process
The drug was based on an active ingredient that had been available for many years at a much lower cost
Yu Y, Hu G, Yin S, Yang X, Zhou M, Jian W
