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Animal studies have shown that monoclonal antibodies targeting GDF15 can prevent weight loss and the onset of cachexia while also slowing the deterioration of cardiac function [108]

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Regulation of autophagy and apoptosis in hepatic stellate cells (HSC) Autophagy and apoptosis are two crucial catabolic pathways for maintaining biological homeostasis, especially in the liver, where dysregulation of these processes can lead to liver fibrosis 95

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