Renal impairment reduces B12 excretion, leading to accumulation
doi: 10.1017/S0007114522002343 19
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It carries copper into the repair processes that build and organize the skins structural matrix
Symptoms of B12 deficiency include: Fatigue Low mood or personality/mood changes Irritability Lethargy Headaches Palpitations Loss of appetite Pale yellow tint to the skin A feeling of pins and needles (paraesthesia) Poor memory Impaired cognitive performance Depression Weakness Impaired digestion Inflammation Gastrointestinal lesions Neurological damage Since B12 is primarily found in animal products, any change in ones diet that leads to a decrease in the consumption of such products such as a vegan , vegetarian, or low-fat diet can increase the chance of a person developing a B12 deficiency
Vitamin B12 is an essential nutrient involved in red blood cell formation, neurological function, DNA synthesis, and cellular energy metabolism