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Patients should also clarify emergency protocols: whom to contact if symptoms worsen, when to seek urgent care, and criteria for temporarily holding semaglutide (such as during severe gastrointestinal symptoms, dehydration, or hospitalization)

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GLP-1 stimulation of the Akt signaling pathway or downregulation of activating transcription factor 4 were two pathways in which GLP-1 stimulation dramatically reduced stress-induced apoptosis (Cai et al., 2017)

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