As the dominant G-actin sequestering protein in mammalian cells, TB-500 binds globular actin with high affinity (Kd ~0.5 M) through a sophisticated triple-contact mechanism involving Lys-3, Lys-18, and Lys-38 residues, preventing spontaneous actin polymerization while maintaining a readily mobilizable reservoir for rapid cytoskeletal reorganization
Use the formula: V draw = D V water M $D$ is your target dose per compound in mg, V water is the BAC water volume you reconstitute with in mL, and $M$ is the single-compound mass in the vial in mg
& Taschler, U
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A signed Certificate of Analysis including HPLC chromatogram and MS spectrum is available for every production lot, request lot-specific COA from your sales contact
Research has documented their role in promoting blood vessel genesis, reducing fibrotic scarring, and supporting recovery from neurological injury