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doi: 10.1016/j.amjmed.2014.10.014 218

Keywords : metabolomics, xanthine, glutathione, tamoxifen resistance, xanthine dehydrogenase Breast cancer is the most diagnosed cancer worldwide, with an estimated 2.3 million new cases in 2020 [1]

Elucidation of plasma-induced chemical modifications on glutathione and glutathione disulphide

So if something goes wrong and the GSSG accumulates, it inhibits an enzyme that relies on the correct oxidation of the ER environment to operate a protein quality control system. Moreover, they discovered, when misfolded proteins dont pass quality control, they wont get exported, so they too pile up in the ER

doi:10.1097/NAN.0000000000000288