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The catalytic core of tyrosinase is composed of H 2 L 2 tetramer, and its active center contains binuclear copper ions, which form a six-coordinated chelating structure through His61, His85, His94(CuA), His259, His263 and His296(CuB) ( 2+ is the key step to catalyze the oxidation of L-tyrosine to dopaquinone, which depends on the precise regulation of the hydrophobic environment in the active chamber ( CuA and CuB are connected by an oxygen bridge to form a rigid structure, required for catalytic activity

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Phospholipidomics analysis in midbrain samples from A53T mice revealed distinct patterns of oxidized phospholipids when compared with the WT littermates (Figure 1H)

Lipase Inhibitors Lipase inhibitors prevent the body from absorbing fat from food, leading to weight loss and improved lipid profiles

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