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In vivo , in a murine monoiodoacetate (MIA)-induced model of OA, a single intra-articular injection of liraglutide reduced synovitis severity, whilst weekly intra-articular injections attenuated behaviour pain responses [95]
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Collagen decline accelerates independently
In 62 evaluable first-line patients, the ORR was 60% (12/20) and 55% with doublet and triplet therapy, respectively