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Higher doses of GLP-1 medications can produce stronger efficacy but also induce more severe side effects, particularly gastrointestinal issues like nausea and vomiting

Enteroendocrine cells, such as L and K cells, sense luminal nutritional and microbial cues and secrete hormones including GLP-1, PYY, and GIP, linking the intestinal microbial environment to appetite regulation, insulin secretion, glucose metabolism, and energy homeostasis [341]

PLoS ONE 6 , e17688 (2011)

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Exenatide and sitagliptin are not associated with increased risk of acute renal failure: a retrospective claims analysis