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Treatment will depend on the underlying cause of amenorrhea

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Tirzepatide (Zepbound) is also FDA-approved for chronic weight management (with criteria) and has strong trial evidence for substantial average weight loss

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Thus, researchers are advised to familiarize themselves with the preferred administration methods in each therapeutic context

A 2025 study in Clinical Gastroenterology and Hepatology (Camilleri et al.) measured colonic 5-HT4 receptor expression in semaglutide patients with persistent constipation vs those who adapted