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Recent clinical data show semaglutide 2.4 mg achieved 14.9% mean weight loss at 68 weeks in STEP 1, while tirzepatidewhich targets dual GLP-1 and GIP receptorsproduces 2027% weight loss in comparable trials, yet individual outcomes vary significantly based on genetic predispositions in appetite and energy metabolism pathways
GLP-1-based therapies for type 2 diabetes: from single, dual and triple agonists to endogenous GLP-1 production and L-cell differentiation
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