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Presented for research literature review only di Ilio C et al

SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis

Methionine is then converted to SAM by methionine adenosyltransferase, and most of the SAM generated is used in transmethylation reactions whereby it is converted to S -adenosylhomocysteine (SAH) by transferring the methyl group to diverse biological acceptors, including proteins and DNA

None of this is surprising, since oxidative stress is closely linked with other forms of aging as well

Further metabolism then takes place via the -oxidation pathway in peroxisomes