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Trial designs differ

Blagih J, Coulombe F, Vincent EE, Dupuy F, Galicia-Vzquez G, Yurchenko E, et al

PMID: 25494545): Association of Afamelanotide With Improved Outcomes in Patients With Erythropoietic Protoporphyria in Clinical Practice , published in JAMA Dermatology (Wensink D et al., 2020

Stool color is only one data point among many, and self-diagnosis based on color alone can miss serious conditions or create unnecessary alarm

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[PMID] Talebi M, Talebi M, Farkhondeh T, Simal-Gandara J, Kopustinskiene DM, Bernatoniene J, et al