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These systems operate through distinct intracellular signaling cascades and respond to different endogenous ligands
Some patients experience stress due to discomfort or worse, trauma, from needles
Starting weight: Patients with more weight to lose often see faster initial results
However, in MASH with significant fibrosis ( F2), pharmacological therapy provides measurable clinical benefits and should be considered with priority, especially if obesity or T2DM coexist (Fig
Algorithm-driven approvals without documented review introduce risk, particularly where complex comorbidities, safeguarding issues or nuanced mental health considerations are present 8,9
doi: 10.17219/acem/61609 70 MondolaPSantilloMDe MercatoRSantangeloF
