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[12] En un ambiente oxidante, se forman puentes disulfuro intermoleculares, y la enzima cambia al estado dimrico activo

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3, 7 They protect cell connections

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In SURMOUNT-1, published in NEJM in 2022, tirzepatide at the 15 mg weekly dose produced a mean placebo-adjusted body weight reduction of 17.8% at 72 weeks in adults with obesity (Jastreboff et al., NEJM, 2022)

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Elucidating its regulatory pathways may offer new therapeutic opportunities for improving DOR

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