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The five subtypes (MC1R to MC5R) are class A G-protein-coupled receptors that signal principally through Gs and adenylyl cyclase to raise intracellular cAMP, and the conserved His-Phe-Arg-Trp core of alpha-MSH is the message sequence recognised by the binding pocket

First introduced as a treatment for Type 2 diabetes and now pursued as a blockbuster weight management therapy, GLP-1 receptor agonists (GLP-1 RAs) have ignited a global scale-up effort that is reshaping the drug manufacturing landscape

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6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells

a, b, n = 3 biologically independent samples

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